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HERO ID
7350532
Reference Type
Journal Article
Title
Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model
Author(s)
Seeni, A; Takahashi, S; Takeshita, K; Tang, M; Sugiura, S; Sato, SY; Shirai, T
Year
2008
Journal
Asian Pacific Journal of Cancer Prevention
ISSN:
2476-762X
Volume
9
Issue
1
Page Numbers
7-14
Language
English
PMID
18439064
Web of Science Id
WOS:000269687200002
Abstract
Research into actions of resveratrol, abundantly present in red grape skin, has been greatly stimulated by its reported beneficial health influence. Since it was recently proposed as a potential prostate cancer chemopreventive agent, we here performed an in vivo experiment to explore its effect in the Transgenic Rat for Adenocarcinoma of Prostate (TRAP) model, featuring the rat probasin promoter/SV 40 T antigen. Resveratrol suppressed prostate cancer growth and induction of apoptosis through androgen receptor (AR) down-regulation, without any sign of toxicity. Resveratrol not only downregulated androgen receptor (AR) expression but also suppressed the androgen responsive glandular kallikrein 11 (Gk11), known to be an ortholog of the human prostate specific antigen (PSA), at the mRNA level. The data provide a mechanistic basis for resveratrol chemopreventive efficacy against prostate cancer.
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