Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7350532

Reference Type

Journal Article

Title

Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model

Author(s)

Seeni, A; Takahashi, S; Takeshita, K; Tang, M; Sugiura, S; Sato, SY; Shirai, T

Year

2008

Journal

Asian Pacific Journal of Cancer Prevention
ISSN: 2476-762X

Volume

Issue

Page Numbers

7-14

Language

English

PMID

18439064

Web of Science Id

WOS:000269687200002

Abstract

Research into actions of resveratrol, abundantly present in red grape skin, has been greatly stimulated by its reported beneficial health influence. Since it was recently proposed as a potential prostate cancer chemopreventive agent, we here performed an in vivo experiment to explore its effect in the Transgenic Rat for Adenocarcinoma of Prostate (TRAP) model, featuring the rat probasin promoter/SV 40 T antigen. Resveratrol suppressed prostate cancer growth and induction of apoptosis through androgen receptor (AR) down-regulation, without any sign of toxicity. Resveratrol not only downregulated androgen receptor (AR) expression but also suppressed the androgen responsive glandular kallikrein 11 (Gk11), known to be an ortholog of the human prostate specific antigen (PSA), at the mRNA level. The data provide a mechanistic basis for resveratrol chemopreventive efficacy against prostate cancer.