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Citation
Tags
HERO ID
7351657
Reference Type
Journal Article
Title
Gene expression analysis reveals a different transcriptomic landscape in female and male breast cancer
Author(s)
Callari, M; Cappelletti, V; De Cecco, L; Musella, V; Miodini, P; Veneroni, S; Gariboldi, M; Pierotti, MA; Daidone, MG
Year
2011
Is Peer Reviewed?
Yes
Journal
Breast Cancer Research and Treatment
ISSN:
0167-6806
EISSN:
1573-7217
Volume
127
Issue
3
Page Numbers
601-610
Language
English
PMID
20625818
DOI
10.1007/s10549-010-1015-8
Web of Science Id
WOS:000290811500002
Abstract
Male breast cancer (MBC) is a poorly characterized disease because of its rarity. Clinical management is based on results obtained from randomized trials conducted in women notwithstanding data in the literature suggesting relevant gender-associated differences in terms of biological and clinical behavior. However, a genome-wide characterization of MBC on a transcriptional level is lacking. In this study, gene expression profiles of 37 estrogen receptor positive (ER+) MBC specimens were compared to that of 53 ER+ Female Breast Cancer (FBC) samples similar for clinical and patho-biological features. Almost 1000 genes were found differentially expressed (FDR < 1%) between female and male patients and biological interpretation highlighted a gender-associated modulation of key biological processes ranging from energy metabolism to regulation of translation and matrix remodeling as well as immune system recruitment. Moreover, an analysis of genes correlated to steroid receptors and ERBB2 suggested a prominent role for the androgen receptor in MBC with a minor relevance for progesterone receptor and ERBB2, although, similarly to FBC, a genomic amplification could be observed. Our findings support the idea that breast cancer is a quite different disease in male and female patients and the underlying gender-related biological differences are likely to have clinical implications connected with different susceptibility to treatment.
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