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73524 
Journal Article 
Contact allergy to styrene and related chemicals 
Sjoborg, S; Fregert, S; Trulsson, L 
1984 
Yes 
Contact Dermatitis
ISSN: 0105-1873
EISSN: 1600-0536 
MUNKSGAARD INT PUBL LTD 
COPENHAGEN 
NIOSH/00146487 
10 
2 
94-96 
English 
6713846 
WOS:A1984SG74500006 
One patient, sensitive to styrene, cross-reacted at patch testing to 2-,3-and 4-vinyltoluene (2-,3-and 4-methylstyrene) and to the metabolites styrene epoxide and 4-vinylphenol (4-hydroxy-styrene). It is assumed that styrene is a prohapten metabolized in the skin by aryl hydrocarbon hydroxylase (AHH) to styrene epoxide acting as the true hapten. Styrene occurs in nature and as a synthetic product. Vinyltoluenes (methylstyrenes) occur as synthetic products in plastics. 4-vinylphenol (4-hydroxystyrene) occurs frequently in different ciders, wines, foods and berries, e.g. cloudberry. 
Dermatitis, Atopic/*chemically induced; Dermatitis, Contact/*etiology; Epoxy Compounds/adverse effects; Food Hypersensitivity/etiology; Haptens/adverse effects; Humans; Patch Tests; Phenols/adverse effects; Styrene; Styrenes/*adverse effects; 0 (Epoxy Compounds); 0 (Haptens); 0 (Phenols); 0 (Styrenes); 100-42-5 (Styrene); 25013-15-4 (vinyltoluene); 2628-17-3 (4-vinylphenol); 96-09-3 (styrene oxide)