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Citation
Tags
HERO ID
7352863
Reference Type
Journal Article
Title
Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival
Author(s)
Nodin, B; Zendehrokh, N; Brändstedt, J; Nilsson, E; Manjer, J; Brennan, DJ; Jirström, K
Year
2010
Is Peer Reviewed?
Yes
Journal
Journal of Ovarian Research
ISSN:
1757-2215
Volume
3
Page Numbers
14
Language
English
PMID
20565760
DOI
10.1186/1757-2215-3-14
Web of Science Id
WOS:000295361200001
Abstract
BACKGROUND:
Altered androgen hormone homeostasis and androgen receptor (AR) activity have been implicated in ovarian carcinogenesis but the relationship between AR expression in ovarian cancer and clinical outcome remains unclear.
METHODS:
In this study, the prognostic impact of AR expression was investigated using immunohistochemistry in tissue microarrays from 154 incident cases of epithelial ovarian cancer (EOC) in the prospective, population-based cohorts Malmö Diet and Cancer Study and Malmö Preventive Project. A subset of corresponding fallopian tubes (n = 36) with no histopathological evidence of disease was also analysed.
RESULTS:
While abundantly expressed in the majority of fallopian tubes with more than 75% positive nuclei in 16/36 (44%) cases, AR was absent in 108/154 (70%) of EOC cases. AR expression was not related to prognosis in the entire cohort, but in the serous subtype (n = 90), AR positivity (> 10% positive nuclei) was associated with a prolonged disease specific survival in univariate (HR= 0.49; 95% CI 0.25-0.96; p= 0.038) and multivariate (HR= 0.46; 95% CI 0.22-0.97; p= 0.042) analysis, adjusted for age, grade and clinical stage.
CONCLUSIONS:
AR expression is considerably reduced in EOC as compared to fallopian tubes, and in EOC of the serous subtype, high AR expression is a favourable prognostic factor. These results indicate that assessment of AR expression might be of value for treatment stratification of EOC patients with serous ovarian carcinoma.
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