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7362073 
Journal Article 
Review 
The circadian clock: pacemaker and tumour suppressor 
Fu, L; Lee, CC 
2003 
1 
Nature Reviews. Cancer
ISSN: 1474-175X
EISSN: 1474-1768 
3 
5 
350-361 
English 
12724733 
WOS:000183007900014 
The circadian rhythms are daily oscillations in various biological processes that are regulated by an endogenous clock. Disruption of these rhythms has been associated with cancer in humans. One of the cellular processes that is regulated by circadian rhythm is cell proliferation, which often shows asynchrony between normal and malignant tissues. This asynchrony highlights the importance of the circadian clock in tumour suppression in vivo and is one of the theoretical foundations for cancer chronotherapy. Investigation of the mechanisms by which the circadian clock controls cell proliferation and other cellular functions might lead to new therapeutic targets.