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HERO ID
7363471
Reference Type
Journal Article
Subtype
Review
Title
Is Testosterone Replacement Therapy in Older Men Effective and Safe?
Author(s)
Yabluchanskiy, A; Tsitouras, PD
Year
2019
Is Peer Reviewed?
Yes
Journal
Drugs and Aging
ISSN:
1170-229X
Volume
36
Issue
11
Page Numbers
981-989
Language
English
PMID
31595418
DOI
10.1007/s40266-019-00716-2
Web of Science Id
WOS:000498641800001
URL
http://link.springer.com/10.1007/s40266-019-00716-2
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Abstract
The number of older adults over 65 years of age is expected to increase to almost 100 million in the US by 2050, more than double the current figure of 46 million. Advanced age is associated with increased frailty among older Americans and often leads to increased disability, hospitalization, institutionalization, and, eventually, mortality. In search of means to improve age-related risks for adverse health outcomes, the question of restoring diminishing sex hormones has gathered much interest and has led to the practice of sex hormone replacement therapies in older men. Recent data suggest that androgen prescription rates in the US for men older than 60 years of age quadrupled from the years 2001 to 2011. While prescription sales of testosterone have increased from $150 million in 2000 to $1.8 billion in 2011, a significant portion of men prescribed testosterone replacement therapy did not meet the laboratory criteria for hypogonadism. While some clinical trials reported an association between testosterone insufficiency in older men and increased risk of death, the exact effects and consequences of testosterone replacement therapy, specifically in older men, remain unclear. This review is aimed at discussing the possible benefits and complications of testosterone replacement therapy in older men over 60 years of age.
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