Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
7366161
Reference Type
Journal Article
Subtype
Review
Title
Apoptosis, autophagy, necroptosis, and cancer metastasis
Author(s)
Su, Z; Yang, Z; Xu, Y; Chen, Y; Yu, Q
Year
2015
Is Peer Reviewed?
1
Journal
Molecular Cancer
ISSN:
1476-4598
Volume
14
Issue
1
Page Numbers
48
Language
English
PMID
25743109
DOI
10.1186/s12943-015-0321-5
URL
http://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-015-0321-5
Exit
Abstract
Metastasis is a crucial hallmark of cancer progression, which involves numerous factors including the degradation of the extracellular matrix (ECM), the epithelial-to-mesenchymal transition (EMT), tumor angiogenesis, the development of an inflammatory tumor microenvironment, and defects in programmed cell death. Programmed cell death, such as apoptosis, autophagy, and necroptosis, plays crucial roles in metastatic processes. Malignant tumor cells must overcome these various forms of cell death to metastasize. This review summarizes the recent advances in the understanding of the mechanisms by which key regulators of apoptosis, autophagy, and necroptosis participate in cancer metastasis and discusses the crosstalk between apoptosis, autophagy, and necroptosis involved in the regulation of cancer metastasis.
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity