Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
7367732
Reference Type
Journal Article
Subtype
Review
Title
Alpha T-catenin (CTNNA3): a gene in the hand is worth two in the nest
Author(s)
Smith, JD; Meehan, MH; Crean, J; Mccann, A
Year
2011
Is Peer Reviewed?
Yes
Journal
Cellular and Molecular Life Sciences (CMLS)
ISSN:
1420-682X
EISSN:
1420-9071
Volume
68
Issue
15
Page Numbers
2493-2498
Language
English
PMID
21598020
DOI
10.1007/s00018-011-0728-0
Web of Science Id
WOS:000293028800001
URL
http://link.springer.com/10.1007/s00018-011-0728-0
Exit
Abstract
Alpha-T-Catenin (CTNNA3) is a key protein of the adherens junctional complex in epithelial cells playing a crucial role in cellular adherence. What makes this gene particularly interesting is that it is located within a common fragile site, is epigenetically regulated, is transcribed through multiple promoters, and generates a variety of alternate transcripts. Finally, CTNNA3 has a nested gene (LRTMM3) embedded within its genomic context transcribed in the opposite direction. Apart from the complexity of its regulation, alterations in both CTNNA3 and LRTMM3 are implicated in human disease.
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity