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7367732 
Journal Article 
Review 
Alpha T-catenin (CTNNA3): a gene in the hand is worth two in the nest 
Smith, JD; Meehan, MH; Crean, J; Mccann, A 
2011 
Yes 
Cellular and Molecular Life Sciences (CMLS)
ISSN: 1420-682X
EISSN: 1420-9071 
68 
15 
2493-2498 
English 
21598020 
WOS:000293028800001 
Alpha-T-Catenin (CTNNA3) is a key protein of the adherens junctional complex in epithelial cells playing a crucial role in cellular adherence. What makes this gene particularly interesting is that it is located within a common fragile site, is epigenetically regulated, is transcribed through multiple promoters, and generates a variety of alternate transcripts. Finally, CTNNA3 has a nested gene (LRTMM3) embedded within its genomic context transcribed in the opposite direction. Apart from the complexity of its regulation, alterations in both CTNNA3 and LRTMM3 are implicated in human disease.