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7368315 
Journal Article 
Review 
Targeting PI3K signalling in cancer: opportunities, challenges and limitations 
Engelman, JA 
2009 
1 
Nature Reviews. Cancer
ISSN: 1474-175X
EISSN: 1474-1768 
9 
8 
550-562 
English 
19629070 
WOS:000268740200013 
There are ample genetic and laboratory studies that suggest the PI3K-Akt pathway is vital to the growth and survival of cancer cells. Inhibitors targeting this pathway are entering the clinic at a rapid pace. In this Review, the therapeutic potential of drugs targeting PI3K-Akt signalling for the treatment of cancer is discussed. I focus on the advantages and drawbacks of different treatment strategies for targeting this pathway, the cancers that might respond best to these therapies and the challenges and limitations that confront their clinical development.