Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
7370654
Reference Type
Journal Article
Subtype
Review
Title
A Perspective on Roles Played by Innate and Adaptive Immunity in the Pathobiology of Neurodegenerative Disorders
Author(s)
Gendelman, HE; Mosley, RLee
Year
2015
Is Peer Reviewed?
Yes
Journal
Journal of NeuroImmune Pharmacology
ISSN:
1557-1890
EISSN:
1557-1904
Volume
10
Issue
4
Page Numbers
645-650
Language
English
PMID
26520433
DOI
10.1007/s11481-015-9639-4
Web of Science Id
WOS:000365727100012
Abstract
Aberrant innate and adaptive immune responses are neurodegenerative disease effectors. Disease is heralded by a generalized, but subtle immune activation orchestrated by the release of extracellular prion-like aggregated and oxidized or otherwise modified proteins. These are responsible for an inflammatory neurotoxic cascade. The perpetrators of such events include effector T cells and activated microglia. What ensues are Alzheimer's and Parkinson's disease, amyotrophic lateral sclerosis and stroke with changed frequencies of effector T cell and reduced numbers or function of regulatory lymphocytes. The control of such immune responses could lead to new therapeutic strategies and the means to effectively combat a composite of diseases that have quite limited therapeutic options.
Keywords
Alzheimer's disease; Parkinson's disease; Amyotrophic lateral sclerosis; Stroke; Adaptive immunity; Regulatory T cells; Effector T cells; Innate immunity; Neuroprotection; Neurodestruction; Neurodegenerative diseases
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity