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7370654 
Journal Article 
Review 
A Perspective on Roles Played by Innate and Adaptive Immunity in the Pathobiology of Neurodegenerative Disorders 
Gendelman, HE; Mosley, RLee 
2015 
Yes 
Journal of NeuroImmune Pharmacology
ISSN: 1557-1890
EISSN: 1557-1904 
10 
4 
645-650 
English 
26520433 
WOS:000365727100012 
Aberrant innate and adaptive immune responses are neurodegenerative disease effectors. Disease is heralded by a generalized, but subtle immune activation orchestrated by the release of extracellular prion-like aggregated and oxidized or otherwise modified proteins. These are responsible for an inflammatory neurotoxic cascade. The perpetrators of such events include effector T cells and activated microglia. What ensues are Alzheimer's and Parkinson's disease, amyotrophic lateral sclerosis and stroke with changed frequencies of effector T cell and reduced numbers or function of regulatory lymphocytes. The control of such immune responses could lead to new therapeutic strategies and the means to effectively combat a composite of diseases that have quite limited therapeutic options. 
Alzheimer's disease; Parkinson's disease; Amyotrophic lateral sclerosis; Stroke; Adaptive immunity; Regulatory T cells; Effector T cells; Innate immunity; Neuroprotection; Neurodestruction; Neurodegenerative diseases