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7381265 
Journal Article 
Review 
The functional role of long non-coding RNA in human carcinomas 
Gibb, EA; Brown, CJ; Lam, WL 
2011 
1 
Molecular Cancer
ISSN: 1476-4598 
10 
38 
English 
21489289 
WOS:000290865000002 
Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however the biological functions of the vast majority remain unknown. Recently, evidence has begun to accumulate describing the molecular mechanisms by which these RNA species function, providing insight into the functional roles they may play in tumorigenesis. In this review, we highlight the emerging functional role of lncRNAs in human cancer.