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7381538 
Journal Article 
Review 
Covalent modifications of histones during development and disease pathogenesis 
Bhaumik, SR; Smith, E; Shilatifard, Ali 
2007 
1 
Nature Structural & Molecular Biology
ISSN: 1545-9993
EISSN: 1545-9985 
14 
11 
1008-1016 
English 
17984963 
WOS:000250766200005 
Covalent modifications of histones are central to the regulation of chromatin dynamics, and, therefore, many biological processes involving chromatin, such as replication, repair, transcription and genome stability, are regulated by chromatin and its modifications. In this review, we discuss the biochemical, molecular and genetic properties of the enzymatic machinery involved in four different types of histone modification: acetylation, ubiquitination, phosphorylation and methylation. We also discuss how perturbation of the activity of this enzymatic machinery can cause developmental defects and disease.