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7384121 
Journal Article 
TRPM8-androgen receptor association within lipid rafts promotes prostate cancer cell migration 
Grolez, GP; Gordiendko, DV; Clarisse, M; Hammadi, M; Desruelles, E; Fromont, G; Prevarskaya, N; Slomianny, C; Gkika, D 
2019 
Yes 
Cell Death & Disease
ISSN: 2041-4889 
10 
9 
652 
English 
31501416 
WOS:000494969700011 
In prostate carcinogenesis, androgens are known to control the expression of the transient receptor potential melastatin 8 (TRPM8) protein via activation of androgen receptor (AR). Overexpression and/or activity of TRPM8 channel was shown to suppress prostate cancer (PCa) cell migration. Here we report that at certain concentrations androgens facilitate PCa cell migration. We show that underlying mechanism is inhibition of TRPM8 by activated AR which interacts with the channel within lipid rafts microdomains of the plasma membrane. Thus, our study has identified an additional nongenomic mechanism of the TRPM8 channel regulation by androgens that should be taken into account upon the development of novel therapeutic strategies.