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Citation
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HERO ID
7391347
Reference Type
Journal Article
Title
DNA methylation in promoter region as biomarkers in prostate cancer
Author(s)
Yang, M; Park, JY
Year
2012
Is Peer Reviewed?
1
Journal
Methods in Molecular Biology
ISSN:
1064-3745
EISSN:
1940-6029
Volume
863
Page Numbers
67-109
Language
English
PMID
22359288
DOI
10.1007/978-1-61779-612-8_5
Abstract
The prostate gland is the most common site of cancer and the second leading cause of cancer death in American men. Recent emerging molecular biological technologies help us to know that epigenetic alterations such as DNA methylation within the regulatory (promoter) regions of genes are associated with transcriptional silencing in cancer. Promoter hypermethylation of critical pathway genes could be potential biomarkers and therapeutic targets for prostate cancer. In this chapter, we updated current information on methylated genes associated with the development and progression of prostate cancer. Over 40 genes have been investigated for methylation in promoter region in prostate cancer. These methylated genes are involved in critical pathways, such as DNA repair, metabolism, and invasion/metastasis. The role of hypermethylated genes in regulation of critical pathways in prostate cancer is discussed. These findings may provide new information of the pathogenesis, the exciting potential to be predictive and to provide personalized treatment of prostate cancer. Indeed, some epigenetic alterations in prostate tumors are being translated into clinical practice for therapeutic use.
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