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7393651 
Journal Article 
Review 
Challenges in circulating tumour cell research 
Alix-Panabières, C; Pantel, K 
2014 
1 
Nature Reviews. Cancer
ISSN: 1474-175X
EISSN: 1474-1768 
14 
9 
623-631 
English 
25154812 
During the past ten years, circulating tumour cells (CTCs) have received enormous attention as new biomarkers and the subject of basic research. Although CTCs are already used in numerous clinical trials, their clinical utility is still under investigation. Many issues regarding the detection and characterization of CTCs remain unknown. In this Opinion article, we propose a conceptual framework of CTC assays and point out current challenges of CTC research, which might structure this dynamic field of translational cancer research.