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7402036 
Journal Article 
Review 
Id family of helix-loop-helix proteins in cancer 
Perk, J; Iavarone, A; Benezra, R 
2005 
1 
Nature Reviews. Cancer
ISSN: 1474-175X
EISSN: 1474-1768 
5 
8 
603-614 
English 
16034366 
WOS:000230881200012 
Over the past few decades, biologists have identified key molecular signatures associated with a wide range of human cancers. Recently, animal models have been particularly useful in establishing whether such signatures have functional relevance; the overexpression of pro-oncogenic or loss of anti-oncogenic factors have been evaluated for their effects on various tumour models. The aim of this review is to analyze the potential role of the inhibitor of DNA binding (Id) proteins in cancer and examine whether deregulated Id activity is tumorigenic and contributes to hallmarks of malignancy, such as loss of differentiation (anaplasia), unrestricted proliferation and neoangiogenesis.