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7415782 
Journal Article 
Evaluation of polysaccharide-based chiral stationary phases in quality control of (S)-mirtazapine 
Rao, RN; Maurya, PK; Guruprasad, M; , 
2012 
Yes 
Biomedical Chromatography
ISSN: 0269-3879
EISSN: 1099-0801 
WILEY-BLACKWELL 
HOBOKEN 
26 
2 
142-146 
English 
21538417 
WOS:000298840300002 
High-performance liquid chromatographic methods were developed for separation of the enantiomers of mirtazapine and its four process-related substances. The direct separations were achieved on chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (Chiralpak AD-H), cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD-H) and cellulose tris(4-methylbenzoate) (Chiralcel OJ-H ). The experimental data were utilized to discuss the effects of the mobile phase composition, the nature of the alcoholic modifier and the specific structural features of the analytes on retention and separation. The elution sequence was determined under the optimized separation conditions. 
Coated polysaccharides phases; Enantioseparation; Liquid chromatography; Mirtazapine; Quality control; alcohol; amylose tris(3,5 dimethylphenylcarbamate); cellulose tris(3,5 dimethylphenylcarbamate); cellulose tris(4 methylbenzoate); mirtazapine; polysaccharide; unclassified drug; article; chirality; drug isolation; drug quality; drug structure; enantiomer; high performance liquid chromatography; quality control; Amylose; Cellulose; Chromatography, High Pressure Liquid; Mianserin; Phenylcarbamates; Stereoisomerism 
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