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7415871 
Journal Article 
Identification of estrogen-responsive genes based on the DNA binding properties of estrogen receptors using high-throughput sequencing technology 
Ikeda, K; Horie-Inoue, K; Inoue, S; , 
2015 
Yes 
Acta Pharmacologica Sinica
ISSN: 1671-4083
EISSN: 1745-7254 
ACTA PHARMACOLOGICA SINICA 
SHANGHAI 
24-31 
English 
25500870 
WOS:000347389000003 
Estrogens are important endocrine hormones that control physiological functions in reproductive organs, and play a pivotal role in the generation and progression of breast cancer. Therapeutic drugs including anti-estrogen and aromatase inhibitors are used to treat patients with breast cancer. The estrogen receptors, ERα and ERβ, function as hormone-dependent transcription factors that directly regulate the expression of their target genes. Therefore, a better understanding of the function and regulation of estrogen-responsive genes provides insight into the gene regulation network associated with breast cancer. Recent technological developments in high-throughput sequencing have enabled the genome-wide identification of estrogen-responsive genes. Further elucidating the estrogen gene cascade is critical for advancements in the diagnosis and treatment of breast cancer.