US EPA

7416458 

Journal Article 

Review 

Recent trends in development of biosensors for detection of microcystin 

Singh, S; Srivastava, A; Oh, HM; Ahn, CY; Choi, GG; Asthana, RK; , 

2012 

1 

Toxicon
ISSN: 0041-0101
EISSN: 1879-3150 

PERGAMON-ELSEVIER SCIENCE LTD 

OXFORD 

60 

5 

878-894 

English 

22732934 

10.1016/j.toxicon.2012.06.005 

WOS:000308121400020 

https://linkinghub.elsevier.com/retrieve/pii/S0041010112005107
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Increased cyanobacterial blooms, a source of cyanotoxins are linked with climate change and eutrophication in aquatic bodies, a major concern worldwide. Microcystins are potently hepatotoxic, nephrotoxic as well as carcinogenic. Thus microcystins are threat to tourism, agriculture and animal's health. However, there is a still lacuna in the knowledge of regulation of microcystins production. Presence of toxic and non-toxic cyanobacterial strains together and occurrence of various microcystin variants in aquatic bodies compounded the problem. Although several analytical techniques for microcystin detection such as bioassay, ELISA, HPLC and LC-MS etc. have been already prevalent, the development of biosensors offered rapid and accurate detection, high reproducibility and portability. Sequencing of Microcystis spp., opened the new vistas towards the development of biosensor at molecular and genetic level. This review incorporates the current trends in the development of biosensors for microcystin detection in the light of state-of-the-art techniques. 

Enzyme biosensor; Immunosensor; Microcystin; Nucleic acid biosensor; microcystin LR; accuracy; aquatic environment; bioassay; biosensor; carcinogenicity; climate change; cyanobacterium; electrochemcial biosensor; electrochemcial DNA biosensor; electrochemcial immunosensor; enzyme based biosensor; enzyme linked immunosorbent assay; eutrophication; evanescent wave fiberoptic immunosensor; fluorescence resonance energy transfer; fluorescent immunosensor; health hazard; high performance liquid chromatography; immunoarray biosensor; immunosensor; intermethod comparison; liquid chromatography; liver toxicity; luminescent immunosensor; mass spectrometry; nephrotoxicity; nonhuman; nuclear magnetic resonance based immunosensor; nucleic acid bioosensor; optical biosensor; optical immunosensor; piezoelectric immunosensor; priority journal; quantitative analysis; reproducibility; review; SPR DNA biosensor; toxin analysis; toxin structure; trend study; Biosensing Techniques; Chemistry Techniques, Analytical; Cyanobacteria; Microcystins; Molecular Structure; Water Pollution; Animalia; Cyanobacteria; Lacuna; Microcystis