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Journal Article 
Primary and Secondary Hypogonadism 
Santi, D; Corona, G; , 
Male hypogonadism is a clinical condition characterized by the impairment of testicular production of both sex steroids and sperm, classically due to a partial or total breakdown of the cross communication between and/or within the hypothalamus, pituitary, and testis. The term, however, is rarely used to identify abnormalities in sperm production, while it is often applied to describe testosterone (T) deficiency (Lenzi et al. 2009).