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7417243 
Journal Article 
Linking Obesity, Metabolism and Cancer 
Vucenik, I; Jones, LP; Mclenithan, JC; , 
2015 
Springer International Publishing 
Cham 
Metabolic Syndrome 
1-21 
Obesity is an urgent and growing global health problem, reaching epidemic proportions. In addition to diabetes and cardiovascular disease, epidemiological evidence shows that people who are obese or overweight are at increased risk of developing some types of cancer. Obesity may also affect tumor progression for many cancers, and obesity presents an obstacle in cancer treatment. In this chapter, we discuss potential mechanisms linking obesity to cancer development, progression, and mortality, including energy imbalance, insulin resistance, and altered hormone signaling. We especially focus on chronic inflammation and its local and systemic effects. Understanding the mechanisms involved in obesity-cancer link is important to prevent both cancer and obesity, but also for developing potential therapeutics.