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7418366 
Journal Article 
Transforming growth factor beta1 targets estrogen receptor signaling in bronchial epithelial cells 
Smith, LC; Moreno, S; Robertson, L; Robinson, S; Gant, K; Bryant, AJ; Sabo-Attwood, T; , 
2018 
1 
Respiratory Research
ISSN: 1465-9921
EISSN: 1465-993X 
BMC 
LONDON 
English 
30165855 
WOS:000443652200001 
Sex differences in idiopathic pulmonary fibrosis (IPF) suggest a protective role for estrogen (E2); however, mechanistic studies in animal models have produced mixed results. Reports using cell lines have investigated molecular interactions between transforming growth factor beta1 (TGF-β1) and estrogen receptor (ESR) pathways in breast, prostate, and skin cells, but no such interactions have been described in human lung cells. To address this gap in the literature, we investigated a role for E2 in modulating TGF-β1-induced signaling mechanisms and identified novel pathways impacted by estrogen in bronchial epithelial cells.