The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7418804

Reference Type

Journal Article

Title

The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition

Author(s)

Tang, SN; Singh, C; Nall, D; Meeker, D; Shankar, S; Srivastava, RK; ,

Year

2010

Is Peer Reviewed?

Yes

Journal

Journal of Molecular Signaling
ISSN: 1750-2187

Page Numbers

Language

English

PMID

20718984

DOI

10.1186/1750-2187-5-14

URL

http://www.jmolecularsignaling.com/articles/10.1186/1750-2187-5-14/
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Abstract

Much attention has been recently focused on the role of cancer stem cells (CSCs) in the initiation and progression of solid malignancies. Since CSCs are able to proliferate and self-renew extensively due to their ability to express anti-apoptotic and drug resistant proteins, thus sustaining tumor growth. Therefore, the strategy to eradicate CSCs might have significant clinical implications. The objectives of this study were to examine the molecular mechanisms by which epigallocathechin gallate (EGCG) inhibits stem cell characteristics of prostate CSCs, and synergizes with quercetin, a major polyphenol and flavonoid commonly detected in many fruits and vegetables.