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7419415 
Journal Article 
The how's and what's of vaccine reactogenicity 
Hervé, C; Laupèze, B; Del Giudice, G; Didierlaurent, AM; Tavares Da Silva, F; , 
2019 
NATURE PUBLISHING GROUP 
LONDON 
English 
31583123 
WOS:000488856700001 
Reactogenicity represents the physical manifestation of the inflammatory response to vaccination, and can include injection-site pain, redness, swelling or induration at the injection site, as well as systemic symptoms, such as fever, myalgia, or headache. The experience of symptoms following vaccination can lead to needle fear, long-term negative attitudes and non-compliant behaviours, which undermine the public health impact of vaccination. This review presents current knowledge on the potential causes of reactogenicity, and how host characteristics, vaccine administration and composition factors can influence the development and perception of reactogenicity. The intent is to provide an overview of reactogenicity after vaccination to help the vaccine community, including healthcare professionals, in maintaining confidence in vaccines by promoting vaccination, setting expectations for vaccinees about what might occur after vaccination and reducing anxiety by managing the vaccination setting.