Gastrin-releasing peptide receptor-based targeting using bombesin analogues is superior to metabolism-based targeting using choline for in vivo imaging of human prostate cancer xenografts | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7420208

Reference Type

Journal Article

Title

Gastrin-releasing peptide receptor-based targeting using bombesin analogues is superior to metabolism-based targeting using choline for in vivo imaging of human prostate cancer xenografts

Author(s)

Schroeder, RP; van Weerden, WM; Krenning, EP; Bangma, CH; Berndsen, S; Grievink-De Ligt, CH; Groen, HC; Reneman, S; de Blois, E; Breeman, WA; de Jong, M; ,

Year

2011

Is Peer Reviewed?

Yes

Journal

European Journal of Nuclear Medicine and Molecular Imaging
ISSN: 1619-7070
EISSN: 1619-7089

Publisher

SPRINGER

Location

NEW YORK

Page Numbers

1257-1266

Language

English

PMID

21431398

DOI

10.1007/s00259-011-1775-3

Web of Science Id

WOS:000292273400008

URL

http://link.springer.com/10.1007/s00259-011-1775-3
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Abstract

Prostate cancer (PC) is a major health problem. Overexpression of the gastrin-releasing peptide receptor (GRPR) in PC, but not in the hyperplastic prostate, provides a promising target for staging and monitoring of PC. Based on the assumption that cancer cells have increased metabolic activity, metabolism-based tracers are also being used for PC imaging. We compared GRPR-based targeting using the (68)Ga-labelled bombesin analogue AMBA with metabolism-based targeting using (18)F-methylcholine ((18)F-FCH) in nude mice bearing human prostate VCaP xenografts.