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7421368 
Journal Article 
Roles of secreted frizzled-related proteins in cancer 
Shi, Y; He, B; You, L; Jablons, DM; , 
2007 
Yes 
Acta Pharmacologica Sinica
ISSN: 1671-4083
EISSN: 1745-7254 
1499-1504 
English 
17723183 
The Wnt signaling pathway is implicated in a variety of biological processes ranging from developmental cell fate to human disease. The components involved in Wnt signaling have been under intense investigation over the last 2 decades. Aberrant canonical Wnt activation has been linked to tumor formation and involves activation of effector molecules or loss of tumor suppressor function. Secreted frizzled-related proteins (sFRPs) are Wnt antagonists. In recent years, accumulating evidence has suggested that sFRPs act as tumor suppressors because their expression is frequently silenced in cancer by promoter hypermethylation. However, sFRPs may also promote cell growth in some contexts. Here, we focus on the known knowledge of sFRPs in tumorigenesis.