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7421890 
Journal Article 
A highly expressed miR-101 isomiR is a functional silencing small RNA 
Llorens, F; Bañez-Coronel, M; Pantano, L; del Río, JA; Ferrer, I; Estivill, X; Martí, E; , 
2013 
Yes 
BMC Genomics
ISSN: 1471-2164 
BMC 
LONDON 
104 
English 
23414127 
WOS:000323336300001 
MicroRNAs (miRNAs) are short non-coding regulatory RNAs that control gene expression usually producing translational repression and gene silencing. High-throughput sequencing technologies have revealed heterogeneity at length and sequence level for the majority of mature miRNAs (IsomiRs). Most isomiRs can be explained by variability in either Dicer1 or Drosha cleavage during miRNA biogenesis at 5' or 3' of the miRNA (trimming variants). Although isomiRs have been described in different tissues and organisms, their functional validation as modulators of gene expression remains elusive. Here we have characterized the expression and function of a highly abundant miR-101 5'-trimming variant (5'-isomiR-101).