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7422412 
Journal Article 
Synthesis and decreasing Aβ content evaluation of arctigenin-4-yl carbamate derivatives 
Xu, X; Li, C; Lei, M; Zhu, Z; Yan, J; Shen, X; Hu, L; , 
2016 
Yes 
Bioorganic & Medicinal Chemistry Letters
ISSN: 0960-894X
EISSN: 1464-3405 
Elsevier Ltd 
26 
13 
2988-2991 
English 
27212069 
WOS:000377470600004 
A series of arctigenin-4-yl carbamate derivatives were synthesized and evaluated for potency in reducing β-amyloid (Aβ) content in HEK293-APPswe cells. Most of the arctigenin-4-yl aralkyl or aryl carbamate derivatives showed improved potency in reducing Aβ content. Among the synthesized compounds, arctigenin-4-yl (3-chlorophenyl)carbamate (20) exhibited the strongest potency with 78.7% Aβ content reduction at 20μM. Furthermore, the effect of arctigenin-4-yl (4-chlorophenyl)carbamate (19) and arctigenin-4-yl (3-chlorophenyl)carbamate (20) on lowing Aβ content was better than arctigenin under the concentrations of 1, 10 and 20μM. 
Arctigenin (ATG); Natural product; Arctigenin-4-yl 3-carbamate; Structure-activity relationships (SARs); Alzheimer's disease (AD) 
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