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7422538 
Journal Article 
Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms 
Lima, ZS; Ghadamzadeh, M; Arashloo, FT; Amjad, G; Ebadi, MR; Younesi, L; , 
2019 
Yes 
Journal of Hematology and Oncology
ISSN: 1756-8722 
BMC 
LONDON 
English 
30975222 
WOS:000464907400002 
Breast cancer is the most common malignancy in women all over the world. Genetic background of women contributes to her risk of having breast cancer. Certain inherited DNA mutations can dramatically increase the risk of developing certain cancers and are responsible for many of the cancers that run in some families. Regarding the widespread multigene panels, whole exome sequencing is capable of providing the evaluation of genetic function mutations for development novel strategy in clinical trials. Targeting the mutant proteins involved in breast cancer can be an effective therapeutic approach for developing novel drugs. This systematic review discusses gene mutations linked to breast cancer, focusing on signaling pathways that are being targeted with investigational therapeutic strategies, where clinical trials could be potentially initiated in the future are being highlighted.