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7423615 
Journal Article 
Basis of Therapeutic Nuclear Medicine 
Elgazzar, AH; Al-Bader, A; Abdel-Dayem, HM; , 
2015 
Springer International Publishing 
Cham 
The Pathophysiologic Basis of Nuclear Medicine 
689-713 
Therapeutic applications of nuclear medicine are expanding (Table 20.1). Until few years ago, the use of radioisotopes in therapy was limited predominantly to treatment of hyperthyroidism, thyroid cancer, and polycythemia rubra vera. Strontium-89 (Sr-89), rhenium-186 (Re-186), samarium-153 (Sm-153), and tin-117m (Sn-117) have been increasingly used more recently in treating bone pain secondary to metastases. Additionally, treatment of certain neuroendocrine tumors with I-131 MIBG and labeled octreotide and pentreotide, the use of radiolabeled monoclonal antibodies for lymphomas, radionuclide treatment of primary and secondary liver lesions, and radionuclide synovectomy have revolutionized the field of therapeutic nuclear medicine.