Design, synthesis, docking study and cytotoxic activity evaluation of some novel letrozole analogs | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7424064

Reference Type

Journal Article

Title

Design, synthesis, docking study and cytotoxic activity evaluation of some novel letrozole analogs

Author(s)

Vosooghi, M; Firoozpour, L; Rodaki, A; Pordeli, M; Safavi, M; Ardestani, SK; Dadgar, A; Asadipour, A; Moshafi, MH; Foroumadi, A; ,

Year

2014

Publisher

SPRINGER INTERNATIONAL PUBLISHING AG

Location

CHAM

Language

English

PMID

25539909

DOI

10.1186/s40199-014-0083-4

Web of Science Id

WOS:000348866400001

URL

http://link.springer.com/10.1186/s40199-014-0083-4
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Abstract

Breast cancer is the most common type of female cancer. One class of hormonal therapy for breast cancer drugs -non steroidal aromatase inhibitors- are triazole analogues. In this work, some derivatives of these drugs was designed and synthesized. All synthesized compounds were evaluated for their cytotoxic activities on breast cancer cell lines (MDA-MB-231, T47D and MCF-7).