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7424075 
Journal Article 
Lupus Anticoagulant-Hypoprothrombinemia Syndrome (LAHPS) 
Shah, MD; , 
2016 
Springer International Publishing 
Cham 
Management of Bleeding Patients 
163-168 
Lupus anticoagulant-hypoprothrombinemia syndrome (LAHPS) is an uncommon disorder, characterized by a positive lupus anticoagulant and an acquired prothrombin deficiency, leading to both a bleeding diathesis and a risk for thrombosis. It is most commonly associated with systemic lupus erythematosus (SLE), but may also be seen with primary antiphospholipid antibody syndrome (APAS), viral infections, or with medications. Rare hemorrhagic manifestations of varying severity do occur in previously healthy children in association with specific coagulation inhibitors, including those directed against factors II, V, VIII, IX, X, XI, and XIII, with and without lupus anticoagulant positivity. The management of children with LAHPS presents a unique challenge as these individuals are at risk for both bleeding and thrombotic sequelae.