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HERO ID
7425548
Reference Type
Journal Article
Title
Flavonoids and Cancer Stem Cells Maintenance and Growth
Author(s)
Kandhari, K; Agraval, H; Sharma, A; Yadav, UCS; Singh, RP; ,
Year
2018
Publisher
Springer Singapore
Location
Singapore
Book Title
Functional Food and Human Health
Page Numbers
587-622
DOI
10.1007/978-981-13-1123-9_26
URL
http://link.springer.com/10.1007/978-981-13-1123-9_26
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Abstract
Normal stem cells are known to possess three important characteristics of self-renewal, restriction on stem cell numbers and ability to divide and differentiate. Compared to normal stem cells, the cancer stem cells (CSCs) have no control on the stem cell numbers. CSCs constitute a miniscule number of cells in the tumour and are responsible for tumour growth, recurrence and progression. CSCs play a vital role in drug resistance, EMT and metastasis, which are responsible for approximately 90% of cancer-related deaths. Thus, targeting CSCs has now gained significant importance in the control and treatment of various cancers. Traditional cancer therapy regimens have not been successful against cancer drug resistance and metastasis. In the recent past, numerous dietary compounds derived from natural sources have been found effective in chemoprevention and treatment of various cancers. Flavonoids are one of such naturally occurring polyphenolic compounds that are found abundantly in fruits, vegetables, tea, seeds, grains, nuts and some traditional medicinal herbs. Various flavonoids have also been shown to have an inhibitory effect on the self-renewal potential and survival of cancer stem cells of different origins. The aim of this chapter is to focus on cancer stem cells and their role in tumour progression and drug resistance and how chemoprevention using flavonoids can become an effective tool to control cancer growth.
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