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HERO ID
7425886
Reference Type
Journal Article
Title
Effects of chronic exposure to microcystin-LR on kidney in mice
Author(s)
Yi, X; Xu, S; Huang, F; Wen, C; Zheng, S; Feng, H; Guo, J; Chen, J; Feng, X; Yang, F
Year
2019
Is Peer Reviewed?
Yes
Journal
International Journal of Environmental Research and Public Health
ISSN:
1661-7827
EISSN:
1660-4601
Volume
16
Issue
24
Page Numbers
5030
Language
English
PMID
31835602
DOI
10.3390/ijerph16245030
Web of Science Id
WOS:000507312700150
Abstract
Microcystin-LR (MC-LR) is a potent hepatotoxin, but a few studies suggested that it might also induce nephrotoxicity. However, nephrotoxicity induced by prolonged oral exposure to MC-LR is unknown. The aim of this study was to evaluate the potential influence of MC-LR on the kidney in mice following chronic exposure to MC-LR. In this study, we evaluated the nephrotoxicity of MC-LR in mice drinking water at different concentrations (1, 30, 60, 90, and 120 μg/L) for 6 months for the first time. The results showed that the kidney weights and the kidney indexes of mice were not altered in the MC-LR treated mice, compared with the control group. In addition, the renal function indicators revealed that the serum creatinine (SCr) levels were not significant changes after exposure to MC-LR. The blood urea nitrogen (BUN) levels were markedly decreased after exposure to 90 and 120μg/L MC-LR for 3 months. The BUN levels were lower than that of the control group after exposure to 120μg/L MC-LR for 6 months. The histopathological investigation revealed enlarged renal corpuscles, widened of kidney tubules, and lymphocyte infiltration in the interstitial tissue and the renal pelvis after exposure to 60, 90, and 120 μg/L MC-LR. Consequently, our results suggested that long-term exposure to MC-LR might be one important risk of kidney injury, which will provide important clues for the prevention of renal impairment.
Keywords
microcystin-LR; chronic oral exposure; nephrotoxicity; mice
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Harmful Algal Blooms- Health Effects
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