US EPA

7426266 

Journal Article 

Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels 

Pinelli, F; Pizzetti, F; Ortolà, ÓF; Marchetti, A; Rossetti, A; Sacchetti, A; Rossi, F; , 

2020 

Yes 

International Journal of Molecular Sciences
ISSN: 1422-0067
EISSN: 14220067 

MDPI 

BASEL 

21 

18 

6621 

English 

32927733 

10.3390/ijms21186621 

WOS:000579999100001 

https://www.mdpi.com/1422-0067/21/18/6621
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In the last years, nanogels have emerged as one of the most promising classes of novel drug delivery vehicles since they can be employed in multiple fields, such as various therapeutics or diagnostics, and with different classes of compounds and active molecules. Their features, such as a high volume to surface ratio, excellent drug loading and release ability, as well as biocompatibility and tunable behavior, are unique, and, nowadays, great efforts are made to develop new formulations that can be employed in a wider range of applications. Polyethylene glycol (PEG)-polyethylenimine (PEI) nanogels probably represent the baseline of this class of biomaterials and they are still largely employed and studied. In any way, the possibility to exploit new core formulations for nanogels is certainly very interesting in order to understand the influence of different polymer chains on the final properties of the system. In this research, we explore and make a comparison between PEG-PEI nanogels and two other different formulations: pluronic F127-PEI nanogels and PEG-Jeffamine nanogels. We propose nanogels synthesis methods, their chemical and physical characterization, as well as their stability analysis, and we focus on the different drug delivery ability that these structures exhibit working with different typologies of drug mimetics. 

Drug release; Nanogel; Polymers; Tunability; biomaterial; carbamic acid; drug carrier; fluorescein sodium; jeffammine; macrogol; nanogel; poloxamer; polyethyleneimine; polymer; pyrene; rhodamine B; unclassified drug; carbamic acid derivative; animal cell; Article; biocompatibility; cytotoxicity; drug delivery system; drug diffusion; drug formulation; drug release; drug stability; embryo; hydrophilicity; hydrophobicity; in vitro study; internalization; microglia; mouse; nonhuman; photon correlation spectroscopy; physical chemistry; proton nuclear magnetic resonance; surface property; synthesis; zeta potential; animal; C57BL mouse; chemistry; comparative study; female; materials testing; pregnancy; primary cell culture; Animals; Carbamates; Drug Delivery Systems; Female; Materials Testing; Mice, Inbred C57BL; Nanogels; Pregnancy; Primary Cell Culture