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7428458 
Journal Article 
Renal Tubular Disorders of Electrolyte Regulation in Children 
Devuyst, O; Belge, H; Konrad, M; Jeunemaitre, X; Zennaro, MC; , 
2016 
Springer Berlin Heidelberg 
Berlin, Heidelberg 
Pediatric Nephrology 
1201-1271 
In 1962, F. Bartter and coworkers described two African American patients presenting a new entity characterized by hypokalemic metabolic alkalosis, renal K+ wasting, hypertrophy and hyperplasia of the juxtaglomerular apparatus, and normotensive hyperaldosteronism [1]. The disorder also featured increased urinary excretion of prostaglandins, high plasma renin activity, and a resistance to the pressor effects of exogenous angiotensin II [1]. For decades, many similar cases and several phenotypic variants have been progressively identified and included in a group of hypokalemic salt-losing tubulopathies, referred to as Bartter-like syndromes [2].