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7429079 
Journal Article 
Review 
Mechanism of action of organophosphorus and carbamate insecticides 
Fukuto, TR; , 
1990 
Yes 
Environmental Health Perspectives
ISSN: 0091-6765
EISSN: 1552-9924 
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE 
RES TRIANGLE PK 
87 
245-254 
English 
2176588 
WOS:A1990DW47600035 
Organophosphorus and carbamate insecticides are toxic to insects and mammals by virtue of their ability to inactivate the enzyme acetylcholinesterase. This review addresses the mechanism of inhibition of acetylcholinesterase by organophosphorus and carbamate esters, focusing on structural requirements necessary for anticholinesterase activity. The inhibition of acetylcholinesterase by these compounds is discussed in terms of reactivity and steric effects. The role of metabolic activation or degradation in the overall intoxication process is also discussed. 
acetylcholinesterase; carbamate insecticide; organophosphate insecticide; arthropod; chemical reaction kinetics; conference paper; enzyme inhibition; nonhuman; theoretical study; toxicokinetics; Arthropoda; Hexapoda; Mammalia 
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