Health & Environmental Research Online (HERO)


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7429211 
Journal Article 
Age-Specific T Cell Homeostasis 
Bourgeois, C; Sauce, D; , 
2018 
Springer International Publishing 
Cham 
Handbook of Immunosenescence 
1-30 
Multiples defects affect adaptive immunity during aging: T cell production (both at thymic and peripheral sites), T cell activation (including TCR sensitivity, proliferation, and differentiation), T cell functions, and T cell survival. Most of these defects directly impact T cell homeostasis. Indeed T cell homeostasis refers to the maintenance of steady state in the body and the physiological processes through which they are regulated. This mechanism ensures a close equilibrium between T cell production and death, two aspects that are drastically affected during aging.