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7429656 
Journal Article 
Topical Fibronectin Improves Wound Healing of Irradiated Skin 
Johnson, MB; Pang, B; Gardner, DJ; Niknam-Benia, S; Soundarajan, V; Bramos, A; Perrault, DP; Banks, K; Lee, GK; Baker, RY; Kim, GH; Lee, S; Chai, Y; Chen, M; Li, W; Kwong, L; Hong, YK; Wong, AK; , 
2017 
1 
Scientific Reports
EISSN: 2045-2322 
NATURE PUBLISHING GROUP 
LONDON 
7 
1 
3876 
English 
28634413 
WOS:000403643900029 
Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, fibronectin was the most significantly and consistently downregulated in radiation-damaged skin. Using a murine model, we confirmed that radiation leads to decreased fibronectin expression in the skin as well as delayed wound healing. Topically applied fibronectin was found to significantly improve wound healing in irradiated skin and was associated with decreased inflammatory infiltrate and increased angiogenesis. Fibronectin treatment may be a useful adjunctive modality in the treatment of non-healing radiation wounds.