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7429975 
Journal Article 
Central Hypogonadism in the Male: Physiopathology, Diagnosis and Treatment 
Rohayem, J; Nieschlag, E; , 
2018 
1-35 
The hypothalamic-pituitary-gonadal (HPG) axis coordinates two functions essential for male reproductive capacity: synthesis and secretion of sex steroid hormones, primarily testosterone, and production of spermatozoa. Our understanding of the physiologic principles of male reproductive health have substantially increased in recent years, enabling physicians not only to identify genetic causes of hypogonadism among a wide spectrum of possible disorders, but also to establish therapeutic strategies. Men with hypothalamic or pituitary disorders nowadays have an excellent prognosis for fertility restoration and for paternity by natural intercourse or using assisted reproductive techniques.