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Citation
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HERO ID
7430114
Reference Type
Journal Article
Subtype
Review
Title
The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway
Author(s)
Furth, N; Aylon, Y; ,
Year
2017
Is Peer Reviewed?
Yes
Journal
Cell Death and Differentiation
ISSN:
1350-9047
EISSN:
1476-5403
Volume
24
Issue
9
Page Numbers
1488-1501
Language
English
PMID
28644436
DOI
10.1038/cdd.2017.99
URL
http://www.nature.com/articles/cdd201799
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Abstract
Proper cellular functionality and homeostasis are maintained by the convergent integration of various signaling cascades, which enable cells to respond to internal and external changes. The Dbf2-related kinases LATS1 and LATS2 (LATS) have emerged as central regulators of cell fate, by modulating the functions of numerous oncogenic or tumor suppressive effectors, including the canonical Hippo effectors YAP/TAZ, the Aurora mitotic kinase family, estrogen signaling and the tumor suppressive transcription factor p53. While the basic functions of the LATS kinase module are strongly conserved over evolution, the genomic duplication event leading to the emergence of two closely related kinases in higher organisms has increased the complexity of this signaling network. Here, we review the LATS1 and LATS2 intrinsic features as well as their reported cellular activities, emphasizing unique characteristics of each kinase. While differential activities between the two paralogous kinases have been reported, many converge to similar pathways and outcomes. Interestingly, the regulatory networks controlling the mRNA expression pattern of LATS1 and LATS2 differ strongly, and may contribute to the differences in protein binding partners of each kinase and in the subcellular locations in which each kinase exerts its functions.
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