US EPA

7432168 

Journal Article 

Overview of Next-Generation Sequencing Technologies and Its Application in Chemical Biology 

Chandran, A; , 

2018 

SPRINGER-VERLAG BERLIN 

BERLIN 

ADVANCING DEVELOPMENT OF SYNTHETIC GENE REGULATORS: WITH THE POWER OF HIGH-THROUGHPUT SEQUENCING IN CHEMICAL BIOLOGY 

1-41 

10.1007/978-981-10-6547-7_1 

WOS:000446321500002 

http://link.springer.com/10.1007/978-981-10-6547-7_1
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Next-generation-sequencing (NGS) technologies enable us to obtain extensive information by deciphering millions of individual DNA sequencing reactions simultaneously. The new DNA-sequencing strategies exceed their precursors in output by many orders of magnitude, resulting in a quantitative increase in valuable sequence information that could be harnessed for qualitative analysis. Sequencing on this scale has facilitated significant advances in diverse disciplines, ranging from the discovery, design, and evaluation of many small molecules and relevant biological mechanisms to maturation of personalized therapies. NGS technologies that have recently become affordable allow us to gain in-depth insight into small-molecule-triggered biological phenomena and empower researchers to develop advanced versions of small molecules. In this chapter we focus on the overlooked implications of NGS technologies in chemical biology, with a special emphasis on small-molecule development and screening. 

978-981-10-6546-0