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7432221 
Journal Article 
Molecular Programs Underlying Asymmetric Stem Cell Division and Their Disruption in Malignancy 
Mukherjee, S; Brat, DJ; , 
2017 
0 
Results and Problems in Cell Differentiation
ISSN: 0080-1844 
SPRINGER INTERNATIONAL PUBLISHING AG 
CHAM 
ASYMMETRIC CELL DIVISION IN DEVELOPMENT, DIFFERENTIATION AND CANCER 
401-421 
English 
28409315 
WOS:000417903300018 
Asymmetric division of stem cells is a highly conserved and tightly regulated process by which a single stem cell produces two unequal daughter cells. One retains its stem cell identity while the other becomes specialized through a differentiation program and loses stem cell properties. Coordinating these events requires control over numerous intra- and extracellular biological processes and signaling networks. In the initial stages, critical events include the compartmentalization of fate determining proteins within the mother cell and their subsequent passage to the appropriate daughter cell in order to direct their destiny. Disturbance of these events results in an altered dynamic of self-renewing and differentiation within the cell population, which is highly relevant to the growth and progression of cancer. Other critical events include proper asymmetric spindle assembly, extrinsic regulation through micro-environmental cues, and non-canonical signaling networks that impact cell division and fate determination. In this review, we discuss mechanisms that maintain the delicate balance of asymmetric cell division in normal tissues and describe the current understanding how some of these mechanisms are deregulated in cancer. 
Tassan, JP; Kubiak, JZ; 
978-3-319-53149-6