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7433190 
Journal Article 
Synthesis of dextroamphetamine sulfate and methamphetamine hydrochloride from D-phenylalanine 
Repke, DB; Bates, DK; Ferguson, WJ; , 
1978 
Yes 
Journal of Pharmaceutical Sciences
ISSN: 0022-3549
EISSN: 1520-6017 
AMER PHARMACEUTICAL ASSN 
WASHINGTON 
67 
8 
1167-1168 
English 
671259 
WOS:A1978FK27100037 
Starting from D-phenylalanine, dextroamphetamine sulfate and methamphetamine hydrochloride were synthesized. The reaction sequence proceeds through three intermediates, in which the absolute configuration of the asymmetric carbon atom is changed but the relative configuration remains the same. Either product can be obtained from a common intermediate by altering the reductive conditions employed for the removal of a carbamate protecting group. 
Dextroamphetamine sulfate—synthesized from D‐phenylalanine; D‐Phenylalanine—starting material for synthesis of dextroamphetamine sulfate and methamphetamine hydrochloride; Methamphetamine hydrochloride—synthesized from D‐phenylalanine; Stimulants, central—dextroamphetamine sulfate and methamphetamine hydrochloride, synthesized from D‐phenylalanine; dexamphetamine; methamphetamine; drug analysis; drug identification; drug structure; drug synthesis; in vitro study; methodology; preliminary communication; theoretical study; Dextroamphetamine; Methamphetamine; Methods; Phenylalanine 
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