Health & Environmental Research Online (HERO)


Print Feedback Export to File
7435244 
Journal Article 
A CONVENIENT, SHORT SYNTHESIS OF DESETHYLCHLOROQUINE [7-CHLORO-4-(4'-ETHYLAMINO-1'-METHYL-BUTYLAMINO)QUINOLINE] 
Ansari, AM; Craig, JC 
1995 
1 
Synthesis
ISSN: 0039-7881
EISSN: 1437-210X 
GEORG THIEME VERLAG 
STUTTGART 
2 
147-149 
English 
WOS:A1995QF89700007 
A short, efficient 2-step synthesis of desethylchloroquine is achieved by generating an internal amide ion from the secondary nitrogen in chloroquine, followed by in situ reaction with 2,2,2-trichloroethyl chloroformate giving rapid elimination of ethylene. The carbamate thus produced easily undergoes deprotection to the target compound at room temperature. 
DESETHYLCHLOROQUINE; N-DEETHYLATION; ELIMINATION REACTION; TRICHLOROETHYL CHLOROFORMATE; INTERNAL AMIDE ION 
Other
• Harmful Algal Blooms- Health Effects
     April 2021 Literature Search
          WOS
          Scopus
          Saxitoxins
               WOS