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HERO ID
7437060
Reference Type
Journal Article
Subtype
Review
Title
A new world of Polycombs: unexpected partnerships and emerging functions
Author(s)
Schwartz, YB; Pirrotta, V; ,
Year
2013
Is Peer Reviewed?
1
Journal
Nature Reviews. Genetics
ISSN:
1471-0056
EISSN:
1471-0064
Volume
14
Issue
12
Page Numbers
853-864
Language
English
PMID
24217316
DOI
10.1038/nrg3603
URL
http://www.nature.com/articles/nrg3603
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Abstract
Polycomb group (PcG) proteins are epigenetic repressors that are essential for the transcriptional control of cell differentiation and development. PcG-mediated repression is associated with specific post-translational histone modifications and is thought to involve both biochemical and physical modulation of chromatin structure. Recent advances show that PcG complexes comprise a multiplicity of variants and are far more biochemically diverse than previously thought. The importance of these new PcG complexes for normal development and disease, their targeting mechanisms and their shifting roles in the course of differentiation are now the subject of investigation and the focus of this Review.
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