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7438926 
Journal Article 
The Biology of Pigmentation 
Dobry, AS; Fisher, DE; , 
2019 
Springer New York 
New York, NY 
Melanoma 
21-50 
Having roots in the earliest Mendelian experiments, the scientific examination of pigmentation offers the unique opportunity to better understand the contributions of genetics, signaling pathways, hormones, and the external environment on the phenotype of our body’s largest organ system: the skin. Epidermal pigmentation is a product of the genetically determined melanin content, the cellular response to external stimuli, and the individual capacity for tanning. These processes are dependent upon a functional pigmentation pathway, which requires proper melanocyte migration, adequate melanogenic enzyme activity, and correct packaging and transfer of melanin to neighboring cells. Disruption of any of these processes leads to alterations in pigmentation. Although cutaneous pigmentation is most heavily focused upon, information about pigment patterning can also be gleaned from other pigmented tissues, including the hair and eyes. Numerous molecular signaling pathways and hormone systems converge to modulate pigment at the cellular level, which further contribute to the overall phenotype. These systems acquire greater importance when considered in the context of melanoma development, as these pathways are frequently found to be dysregulated.