US EPA

7438938 

Journal Article 

Notch Signaling: From Neurogenesis to Neurodegeneration 

Sachan, N; Mutsuddi, M; Mukherjee, A; , 

2019 

Springer Singapore 

Singapore 

Insights into Human Neurodegeneration: Lessons Learnt from Drosophila 

185-221 

10.1007/978-981-13-2218-1_7 

WOS:000618610700007 

http://link.springer.com/10.1007/978-981-13-2218-1_7
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Notch signaling pathway plays a pivotal role during development of an organism. The Notch pathway is an evolutionarily conserved signaling system which has been shown to play a major role in cell fate determination, differentiation, proliferation and apoptotic events, as well as self-renewal processes of different tissues. The same pathway can be deployed in numerous cellular contexts to play varied and critical roles for the development of an organism. In Drosophila embryo, loss of Notch function produces remarkable excess of neurons at the expense of the epidermis, and hence Notch was identified as a "neurogenic gene". Several studies have revealed the importance of Notch in the nervous system, including in the maintenance of immature neurons and the control of neurite outgrowth of differentiated neurons. Notch signaling also contributes to the regulation of synaptic plasticity and olfactory functions in the adult brain. Notch signaling has been known to play a crucial role in neural stem cell maintenance and neurogenesis in embryonic as well as adult brain. Thus, it is not surprising that aberrant Notch function can lead to various neurodegenerative diseases. The wealth of genetic resources available for flies offers a unique opportunity to dissect involvement of Notch signaling in neurodegeneration. Understanding the different spatiotemporal regulatory mechanisms of Notch signaling and involvement of Notch signaling pathway in neurodegeneration will help to comprehend various underlying causes of human neurodegenerative diseases at the molecular level. 

Mutsuddi, M; Mukherjee, A; 

978-981-13-2217-4