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7439007 
Journal Article 
Curcumin in the Management of Endometriosis 
Ohaegbulam, G; Chowdhury, I; Thompson, WE; , 
2020 
Springer International Publishing 
Cham 
Endometriosis in Adolescents 
663-677 
Endometriosis is a chronic gynecological inflammatory disorder in which the immune system dysregulation is thought to play a role in its initiation and progression. Due to altered sex steroid receptor concentrations and other signaling defects, endometriotic tissues have an attenuated response to hormonal treatment. This hormonal resistance contributes to lesion survival, proliferation, and infertility. Current agency-approved hormonal therapies, including synthetic progestins, GnRH agonists, and danazol, are often of limited efficacy and counterproductive to fertility and cause systemic side effects due to suppression of endogenous steroid hormone levels. In this chapter, we highlighted the curcumin (diferuloylmethane, CUR), which has long been used as an anti-inflammatory folk medicine in Asian countries for this condition.