US EPA

7439350 

Journal Article 

The Epidemiology and Pathogenesis of Sarcoma 

Kabir, W; Choong, PFM; , 

2021 

Springer Singapore 

Singapore 

Sarcoma 

11-27 

10.1007/978-981-15-9414-4_2 

http://link.springer.com/10.1007/978-981-15-9414-4_2
Exit
 

Sarcomas are a group of rare malignant neoplasms of mesenchymal origin which may occur in skeletal and extraskeletal tissue, including muscles, tendons, fat, synovium, fibrous tissue, blood vessels and the peripheral nervous system [1, 2]. Tumours of soft tissue and bone are characterised by a high degree of morphological, molecular and clinical heterogeneity. Sarcomas are classified by the World Health Organization (WHO) according to histological features into over 100 types, of which at least 70% are soft tissue sarcomas [2, 3]. The classification system for sarcomas is an evolving process, reflecting the advent of novel molecular, cytogenetic and immunohistochemical techniques which facilitate the identification of groups of sarcoma cells expressing tumour-specific markers [4]. These techniques play a pivotal role in the refinement of sarcoma diagnosis, which is currently based on tumour morphology, immunohistochemistry and clinic-pathological correlation [2].